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RE: Endogenous retroviruses

 
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RE: Endogenous retroviruses - 7/22/2008 10:54:01 AM   
Jhud


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quote:

Yes they can be beneficial. For instance, LTRs have regulatory sequences that can regulate nearby genes. (ie: salivary amylase, ZNF80, cytochrome c1, Kruppel-like H-plk and phospholipase A2-L (PLA2L))

Source: Larsson E & Andersson G. Beneficial Role of Human Endogenous Retroviruses: Facts and Hypotheses. Scandinavian Journal of Immunology. 48:329-338 (1998)


So, as much as they are beneficial, then they don't neccesarily render the human genome 'imperfect' - i.e., less functional?

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RE: Endogenous retroviruses - 7/22/2008 11:01:49 AM   
HHV5

 

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quote:

ORIGINAL: Jhud

quote:

Yes they can be beneficial. For instance, LTRs have regulatory sequences that can regulate nearby genes. (ie: salivary amylase, ZNF80, cytochrome c1, Kruppel-like H-plk and phospholipase A2-L (PLA2L))

Source: Larsson E & Andersson G. Beneficial Role of Human Endogenous Retroviruses: Facts and Hypotheses. Scandinavian Journal of Immunology. 48:329-338 (1998)


So, as much as they are beneficial, then they don't neccesarily render the human genome 'imperfect' - i.e., less functional?


ERVs also cause genomic instability and can turn on proto-oncogenes.

ERVs are both beneficial and harmful - imperfect.
Post #: 27
RE: Endogenous retroviruses - 7/22/2008 11:02:45 AM   
Method

 

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quote:

ORIGINAL: Jhud

quote:

Yes they can be beneficial. For instance, LTRs have regulatory sequences that can regulate nearby genes. (ie: salivary amylase, ZNF80, cytochrome c1, Kruppel-like H-plk and phospholipase A2-L (PLA2L))

Source: Larsson E & Andersson G. Beneficial Role of Human Endogenous Retroviruses: Facts and Hypotheses. Scandinavian Journal of Immunology. 48:329-338 (1998)


So, as much as they are beneficial, then they don't neccesarily render the human genome 'imperfect' - i.e., less functional?


The vast majority of ERV's have vestigial function. They may have rudimentary or secondary roles other than producing viral capsids, roles such as taking up space to absorb environmentally caused mutations.
Post #: 28
RE: Endogenous retroviruses - 7/22/2008 11:04:27 AM   
Jhud


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quote:

ERVs also cause genomic instability and can turn on proto-oncogenes.

ERVs are both beneficial and harmful - imperfect.


Of course those which are harmful are imperfect, that is a given. A broken bone is harmful - but that doesn't mean the existence of bones are an indicator of imperfection does it?

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RE: Endogenous retroviruses - 7/22/2008 11:04:55 AM   
Bettawrekonize

 

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ORIGINAL: HHV5
I wasn't responding to a criticism. I was responding to a question that tries to simplify a complex subject.


It was a simple yes or no question, but you had to unnecessarily complicate it like politicians unnecessarily do the same thing.

quote:


Politics, like evolution, is not simple.


At least you tacitly acknowledge that evolution is political (and not scientific) in nature.
Post #: 30
RE: Endogenous retroviruses - 7/22/2008 11:08:57 AM   
HHV5

 

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quote:

ORIGINAL: Jhud

quote:

ERVs also cause genomic instability and can turn on proto-oncogenes.

ERVs are both beneficial and harmful - imperfect.


Of course those which are harmful are imperfect, that is a given. A broken bone is harmful - but that doesn't mean the existence of bones are an indicator of imperfection does it?


That's assuming the function of ERV is to be beneficial.

As Method said before, ERVs are mutations - beneficial, detrimental, or neutral - any beneficial or detrimental function is vestigial.
Post #: 31
RE: Endogenous retroviruses - 7/22/2008 11:10:50 AM   
gluadys

 

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quote:

ORIGINAL: Jhud

So, as much as they are beneficial, then they don't neccesarily render the human genome 'imperfect' - i.e., less functional?


Ah, so you are taking the position that there is more than one way to be genetically perfect?

I'm comfortable with that, but I don't know if the proponents of "original genetic perfection" would be.

There is still the question of the historical origin of ERVS that you have not responded to.
Post #: 32
RE: Endogenous retroviruses - 7/22/2008 11:12:50 AM   
HHV5

 

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quote:

ORIGINAL: Bettawrekonize

quote:

ORIGINAL: HHV5
I wasn't responding to a criticism. I was responding to a question that tries to simplify a complex subject.


It was a simple yes or no question, but you had to unnecessarily complicate it like politicians unnecessarily do the same thing.

quote:


Politics, like evolution, is not simple.


At least you tacitly acknowledge that evolution is political (and not scientific) in nature.


I tacitly acknowledged nothing of the sort. If you're going to make a case, at least be logical.

No one was talking about politics. You only brought it up because you had nothing else to contribute to this thread.
Post #: 33
RE: Endogenous retroviruses - 7/22/2008 11:16:53 AM   
Jhud


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quote:

That's assuming the function of ERV is to be beneficial.

As Method said before, ERVs are mutations - beneficial, detrimental, or neutral - any beneficial or detrimental function is vestigial.


I really don't care how you or Method think it got there (and incidentaly it wasn't a 'mutation' in the ordinary sense of the word - it is an introduction of genetic material from an outside agent) I simply want to know why a beneficial ERV would make a human genome 'imperfect'?

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
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Post #: 34
RE: Endogenous retroviruses - 7/22/2008 11:20:49 AM   
HHV5

 

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quote:

ORIGINAL: Jhud

quote:

That's assuming the function of ERV is to be beneficial.

As Method said before, ERVs are mutations - beneficial, detrimental, or neutral - any beneficial or detrimental function is vestigial.


I really don't care how you or Method think it got there (and incidentaly it wasn't a 'mutation' in the ordinary sense of the word - it is an introduction of genetic material from an outside agent) I simply want to know why a beneficial ERV would make a human genome 'imperfect'?


But not all ERVs are beneficial.

But it would be imperfect because any change from perfection is inherently imperfect.

And it is a mutation. Incorporation of an ERV into the chromosome is a change in nucleotide sequence.
Post #: 35
RE: Endogenous retroviruses - 7/22/2008 11:23:15 AM   
Jhud


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quote:

Ah, so you are taking the position that there is more than one way to be genetically perfect?

I'm comfortable with that, but I don't know if the proponents of "original genetic perfection" would be.

There is still the question of the historical origin of ERVS that you have not responded to.


First off, I want to make it exceedingly clear that as a critical thinker, I am not beholden to 'proponents' of anything. I don't worry like many evolutionists do around here about towing the party line, I think critically, and am a skeptic in the truest sense of the word, so 'warning' me about what others think is a useless rhetorical device.

Secondly, you were the one who introduced the notion of perfection as a standard of measurement into this conversation, without of course defining it - I think I have shown that as much as we can call anything in a temporal, changing world 'perfect' (and I personally don't know where the notion came from to begin with) an ERV can either lend itself to that end, or detract from it.

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
- Ronald Reagan
Post #: 36
RE: Endogenous retroviruses - 7/22/2008 11:26:25 AM   
Jhud


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quote:

But not all ERVs are beneficial.

But it would be imperfect because any change from perfection is inherently imperfect.

And it is a mutation. Incorporation of an ERV into the chromosome is a change in nucleotide sequence.


Well, first off I make no claim of 'perfection' of the human genome because there is to my knowledge no objective definition of human genetic perfection.

Secondly, as much as I have shown, and you have agreed, that ERVs can be good and useful, they certainly don't detract from whatever standard you suppose the human genome to have orginiated with.

That the human genome is no longer wholly functional and benficial is something I have never contested.

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
- Ronald Reagan
Post #: 37
RE: Endogenous retroviruses - 7/22/2008 11:30:51 AM   
HHV5

 

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Adam would have had genetic perfection. Any addition to his genome is by definition imperfect because any change to perfection cannot be perfect.
Post #: 38
RE: Endogenous retroviruses - 7/22/2008 11:38:04 AM   
Jhud


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Adam would have had genetic perfection. Any addition to his genome is by definition imperfect because any change to perfection cannot be perfect.


Saying that doesn't provide an objective measure of genetic perfection, nor is there any reason to believe Adam was genetically 'perfect' whatever the definition of that might be.

In short, you don't know perfection from Adam.

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
- Ronald Reagan
Post #: 39
RE: Endogenous retroviruses - 7/22/2008 11:41:30 AM   
HHV5

 

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quote:

ORIGINAL: Jhud

quote:

Adam would have had genetic perfection. Any addition to his genome is by definition imperfect because any change to perfection cannot be perfect.


Saying that doesn't provide an objective measure of genetic perfection, nor is there any reason to believe Adam was genetically 'perfect' whatever the definition of that might be.

In short, you don't know perfection from Adam.


But Adam was created perfectly....
Post #: 40
RE: Endogenous retroviruses - 7/22/2008 11:44:09 AM   
Method

 

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quote:

ORIGINAL: Jhud
Secondly, as much as I have shown, and you have agreed, that ERVs can be good and useful, they certainly don't detract from whatever standard you suppose the human genome to have orginiated with.


What if an ERV is detrimental? What then?

quote:

That the human genome is no longer wholly functional and benficial is something I have never contested.


When has it ever been wholly functional and beneficial?
Post #: 41
RE: Endogenous retroviruses - 7/22/2008 11:48:35 AM   
Jhud


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quote:

What if an ERV is detrimental? What then?


Then it would be detrimental!?

quote:

When has it ever been wholly functional and beneficial?


That is something I don't think we could know empirically, though I believe it to be so.

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
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Post #: 42
RE: Endogenous retroviruses - 7/22/2008 11:49:35 AM   
Jhud


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quote:

But Adam was created perfectly....


And where did you get that from?

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Post #: 43
RE: Endogenous retroviruses - 7/22/2008 12:14:36 PM   
HHV5

 

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quote:

ORIGINAL: Jhud

quote:

But Adam was created perfectly....


And where did you get that from?


Adam was created in God's image. God's creation was not imperfect. At the very least, Adam's original genome would not have contained ERVs because they are both beneficial and harmful, so by definition, ERVs are imperfect.

Do you believe the Earth is roughly 6000 years old?
Post #: 44
RE: Endogenous retroviruses - 7/22/2008 12:28:18 PM   
Jhud


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quote:

Adam was created in God's image. God's creation was not imperfect. At the very least, Adam's original genome would not have contained ERVs because they are both beneficial and harmful, so by definition, ERVs are imperfect.


Well, you seem vaguely to be citing Genesis - where in Genesis does it specifically say that Adam was created perfect, genetically or otherwise?

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
- Ronald Reagan
Post #: 45
RE: Endogenous retroviruses - 7/22/2008 12:56:15 PM   
Method

 

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quote:

ORIGINAL: Jhud
Then it would be detrimental!?


Then ID/creationism is quite vague where it concerns ERV's. Some claim that ERV's have function and are therefore designed. Would this mean that non-functional or detrimental ERV's evidence non-design? It would appear not, so the argument that functional ERV's evidence ID really isn't much of an argument.

quote:

That is something I don't think we could know empirically, though I believe it to be so.


Fair enough. My incredulity is still piqued due to the fact that there are around 200,000 ERV's in the human genome and pseudogenes outnumber functional genes. That's a lot of added function, so much so that I can't imagine that humans would look anything like modern humans, but I could be wrong.
Post #: 46
RE: Endogenous retroviruses - 7/22/2008 1:00:08 PM   
HHV5

 

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quote:

ORIGINAL: Jhud

quote:

Adam was created in God's image. God's creation was not imperfect. At the very least, Adam's original genome would not have contained ERVs because they are both beneficial and harmful, so by definition, ERVs are imperfect.


Well, you seem vaguely to be citing Genesis - where in Genesis does it specifically say that Adam was created perfect, genetically or otherwise?


Did God originally create a flawed human being?
Post #: 47
RE: Endogenous retroviruses - 7/22/2008 1:15:48 PM   
Jhud


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quote:

Did God originally create a flawed human being?


There are only two choices - 'flawed' and 'perfect'?

But even if you assert that humans were created 'perfect' you must tell us what the Scriptural definition of genetic perfection is - do you have that available on your concordance there?

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
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Post #: 48
RE: Endogenous retroviruses - 7/22/2008 1:18:13 PM   
Jhud


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quote:

Then ID/creationism is quite vague where it concerns ERV's. Some claim that ERV's have function and are therefore designed. Would this mean that non-functional or detrimental ERV's evidence non-design? It would appear not, so the argument that functional ERV's evidence ID really isn't much of an argument.


ID doesn't claim that everything that occurs in the natural world is the product of design - if it did, then we wouldn't need ID.

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It has been said that politics is the second oldest profession. I have learned that it bears a striking resemblance to the first..
- Ronald Reagan
Post #: 49
RE: Endogenous retroviruses - 7/22/2008 1:54:26 PM   
HHV5

 

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quote:

ORIGINAL: Jhud

quote:

Did God originally create a flawed human being?


There are only two choices - 'flawed' and 'perfect'?

But even if you assert that humans were created 'perfect' you must tell us what the Scriptural definition of genetic perfection is - do you have that available on your concordance there?


Perfection is the absence of flaw.

Scripture is silent on genetics (and on numerous other subjects), but if you read Genesis literally, Adam was in the image of God, perfect. Therefore, his genomic makeup was also perfect. That precludes design with ERV already incorporated into the genome.
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